ABSTRACT
El carcinoma de células en anillo de sello es una variante histopatológica de cáncer gástrico que se encuentra en aumento, se caracteriza por un mal pronóstico. Se presenta el caso de un hombre joven al que se le hizo este diagnóstico en el contexto de una complicación rara como es el síndrome de estenosis gastroduodenal.
Signet ring cell carcinoma is a histopathological variant of gastric cancer that is increasing and is characterized by a poor prognosis. We present the case of a young man who underwent this diagnosis in the context of a rare complication such as upper gastrointestinal stenosis syndrome.
O carcinoma de células em anel de sinete é uma variante histopatológica do câncer gástrico que está aumentando e é caracterizado por um mau prognóstico. É apresentado o caso de um jovem que recebeu este diagnóstico no contexto de uma complicação rara como a síndrome de estenose gastroduodenal.
Subject(s)
Humans , Male , Adult , Stomach Neoplasms/diagnosis , Carcinoma, Signet Ring Cell/diagnosis , Stomach Neoplasms/surgery , Stomach Neoplasms/complications , Carcinoma, Signet Ring Cell/surgery , Carcinoma, Signet Ring Cell/complications , Constriction, Pathologic/etiology , GastrectomyABSTRACT
Se denomina mieloptisis a la infiltración de la médula ósea por células no hematopoyéticas. En pacientes con cáncer gástrico esta invasión es extremadamente infrecuente y la supervivencia suele ser menor a tres meses. Presentamos el caso de un hombre de 35 años con compromiso de la médula ósea secundario a un carcinoma gástrico difuso de células en anillo de sello.
The infiltration of the bone marrow y non-hematopoietic cells is called myelophthisis. In patients with gastric cancer, this invasion is extremely infrequent and the survival is usually less than three months. We present the case of a 35-year-old man with bone marrow involvement secondary to diffuse gastric carcinoma of signet ring cells.
Subject(s)
Humans , Male , Adult , Stomach Neoplasms/diagnosis , Carcinoma, Signet Ring Cell/diagnosis , Anemia, Myelophthisic/diagnosis , Stomach Neoplasms/complications , Stomach Neoplasms/drug therapy , Fatal Outcome , Carcinoma, Signet Ring Cell/complications , Carcinoma, Signet Ring Cell/drug therapy , Anemia, Myelophthisic/etiologyABSTRACT
This case study describes a 71-year-old man with signet-ring cell gastric adenocarcinoma and malignant sigmoidal polyp; and typical features of Saint's triad and Heyde syndrome. He had digestive bleeding, two types of hernia, diverticulosis, arterial hypertension, malignant polyp, and antecedent of smoking, lung tuberculosis, and surgical correction of aortic valve stenosis. There is a hypothetical inverse relationship between herniosis and development of malignancy; however, the patient herein described presented gastric and sigmoidal cancers. Gastrointestinal malignancies are sometimes associated with paraneoplastic entities, isolated or manifested as syndromes, but neither Saint's triad or Heyde syndrome have been included. This patient persisted clinically stable during the preoperative period, but suddenly died; Trousseau's syndrome would be the most probable mechanism of sudden death in this setting. Case reports can stimulate further studies to get additional knowledge about unusual entities.
Este estudio de caso describe un hombre de 71 años de edad, con adenocarcinoma gástrico con células en anillo de sello y un pólipo maligno sigmoideo; y características típicas de la tríada de Saint y del síndrome de Heyde. Tuvo una hemorragia digestiva, dos tipos de hernias, divertículos, hipertensión arterial, y pólipo maligno; con antecedente de tabaquismo, tuberculosis pulmonar, y corrección quirúrgica de estenosis de la válvula aórtica. Hay una hipotética relación inversa entre hernioses y el desarrollo de malignidades; sin embargo, el paciente que se describe en el presente documento presentó cánceres gástrico y sigmoideo. Neoplasias gastrointestinales se asocian a veces con entidades para neoplásicas aisladas o manifiestan síndromes, pero ni la tríada de Saint ni el síndrome de Heyde se ha incluido. Este paciente persistió clínicamente estable durante el período preoperatorio, pero de repente murió; síndrome de Trousseau sería el mecanismo más probable de muerte súbita en esta situación. Los informes de casos pueden estimular más estudios para obtener un conocimiento adicional sobre esas entidades inusuales.
Subject(s)
Aged , Humans , Male , Aortic Valve Stenosis/complications , Sigmoid Neoplasms/complications , Stomach Neoplasms/complications , Cholelithiasis/complications , Colonic Polyps/complications , Diverticulum/complications , Carcinoma, Signet Ring Cell/complications , Gastrointestinal Hemorrhage/etiology , Hernia, Hiatal/complications , Neoplasms, Multiple Primary/complications , Syndrome , Thrombophlebitis/etiology , Angiodysplasia/etiology , Fatal Outcome , Anemia, Iron-Deficiency/etiology , Death, Sudden , Models, BiologicalABSTRACT
We report a case of 50-year-old male with obstructive jaundice diagnosed as peri-ampullary collision tumor comprising of large cell neuroendocrine carcinoma and signet ring cell carcinoma. The association of neuroendocrine (usually carcinoids) and adenocarcinoma is extremely uncommon with only few case reports available in the reported literature.
Subject(s)
Carcinoma, Neuroendocrine/complications , Carcinoma, Neuroendocrine/diagnosis , Carcinoma, Neuroendocrine/pathology , Carcinoma, Signet Ring Cell/complications , Carcinoma, Signet Ring Cell/diagnosis , Carcinoma, Signet Ring Cell/pathology , Common Bile Duct Neoplasms/diagnosis , Common Bile Duct Neoplasms/pathology , Histocytochemistry , Homeodomain Proteins/analysis , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Male , Microscopy , Middle Aged , Radiography, Abdominal , Synaptophysin/analysis , Trans-Activators/analysisABSTRACT
Microangiopathic hemolytic anemia (MAHA) occurs occasionally as a paraneoplastic syndrome in some solid tumors, but MAHA accompanied by signet ring cell carcinoma of an unknown origin is very rare. In this study, we present the case of an 80-yr-old man who was admitted to the hospital because of a 1-month history of lower back pain and dyspnea. He was diagnosed with MAHA on the basis of the laboratory findings that revealed anemia with schistocytes, decreased haptoglobin levels, and a negative direct Coombs' test. Bone marrow examination, which was performed because of the progression of anemia, revealed bone marrow metastases of signet ring cell carcinoma with extensive bone marrow necrosis. However, the primary origin of this signet ring cell carcinoma was not found. When the cause of progressive MAHA is unknown, the possibility of cancer-associated MAHA must be excluded by performing additional tumor workup, including the detection of tumor markers, gastric and colorectal endoscopic examinations, bone marrow examinations, and positron emission tomography-computed tomography or bone scans.
Subject(s)
Aged, 80 and over , Humans , Male , Bone Marrow Neoplasms/complications , Carcinoma, Signet Ring Cell/complications , Endoscopy, Gastrointestinal , Haptoglobins/metabolism , Immunohistochemistry , Necrosis/etiology , Neoplasm Metastasis , Positron-Emission Tomography , Purpura, Thrombotic Thrombocytopenic/diagnosis , Tomography, X-Ray Computed , Biomarkers, Tumor/analysisABSTRACT
Microangiopathic hemolytic anemia (MAHA) occurs occasionally as a paraneoplastic syndrome in some solid tumors, but MAHA accompanied by signet ring cell carcinoma of an unknown origin is very rare. In this study, we present the case of an 80-yr-old man who was admitted to the hospital because of a 1-month history of lower back pain and dyspnea. He was diagnosed with MAHA on the basis of the laboratory findings that revealed anemia with schistocytes, decreased haptoglobin levels, and a negative direct Coombs' test. Bone marrow examination, which was performed because of the progression of anemia, revealed bone marrow metastases of signet ring cell carcinoma with extensive bone marrow necrosis. However, the primary origin of this signet ring cell carcinoma was not found. When the cause of progressive MAHA is unknown, the possibility of cancer-associated MAHA must be excluded by performing additional tumor workup, including the detection of tumor markers, gastric and colorectal endoscopic examinations, bone marrow examinations, and positron emission tomography-computed tomography or bone scans.
Subject(s)
Aged, 80 and over , Humans , Male , Bone Marrow Neoplasms/complications , Carcinoma, Signet Ring Cell/complications , Endoscopy, Gastrointestinal , Haptoglobins/metabolism , Immunohistochemistry , Necrosis/etiology , Neoplasm Metastasis , Positron-Emission Tomography , Purpura, Thrombotic Thrombocytopenic/diagnosis , Tomography, X-Ray Computed , Biomarkers, Tumor/analysisABSTRACT
To report a case of signet ring cell adenoma of the thyroid which is an extremely rare thyroid lesion. A 25-year-old female patient presented with a goiter and dysphagia that had been present for the last 1 year before admission. Physical examination revealed a palpable solitary nodule in the right lobe of the thyroid. The ultrasonogram demonstrated multiple nodules among which the most remarkable one was 15 x 24 mm in size, in the right lobe of the thyroid. After surgical excision, the lesion was found to be consistent with signet ring cell adenoma characterized by the presence of round to oval signet ring cells with large cytoplasmic vacuoles and hyperchromatic eccentric nuclei. Intracytoplasmic thyroglobulin, periodic acid-Schiff [PAS] with and without diastase and combined Alcian-blue-PAS were all positive. Pathologists should keep this rare primary tumor of the thyroid in mind when examining thyroid lesions and should not confound it with metastatic signet ring cell carcinoma of the thyroid
Subject(s)
Humans , Female , Adult , Carcinoma, Signet Ring Cell/complications , Thyroid Neoplasms/pathology , Thyroid Neoplasms/complications , Goiter/etiology , Deglutition DisordersABSTRACT
Small bowel tumors occur rarely. We present an unusual case of a 68 year old man with gastric outlet obstruction secondary to a non-ampullary primary duodenal signet ring cell carcinoma. A review of the literature of small bowel malignant tumors is presented along with the case.
Subject(s)
Humans , Male , Aged , Carcinoma, Signet Ring Cell/complications , Duodenal Neoplasms/complications , Gastric Outlet Obstruction/etiology , Carcinoma, Signet Ring Cell/diagnosis , Duodenal Neoplasms/diagnosisABSTRACT
We report a 56-year-old lady with chronic diarrhea and weight loss. She had undergone lumpectomy with axillary clearance (node positive) four years ago for invasive lobular carcinoma of breast. Investigations revealed involvement of almost the entire gut with skip areas. Biopsies from the stomach showed presence of signet-ring cells, suggestive of metastases from invasive lobular carcinoma of breast. Estrogen receptor immuno-staining was positive, confirming the diagnosis. She was treated initially with octreotide and later with chemotherapeutic agents, with transient relief in diarrhea. She succumbed eight months later.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Lobular/secondary , Carcinoma, Signet Ring Cell/complications , Chronic Disease , Diarrhea/etiology , Fatal Outcome , Female , Humans , Middle Aged , Stomach Neoplasms/complications , Weight LossABSTRACT
Signet ring cell carcinoma is a unique mucin secreting adenocarcinoma. It generally arises from stomach, colon, rectum or breast and rarely from lung. Pleural membrane involvement is common in lung cancer manifesting as pleural effusion. Rarely, it may encase the whole lung without effusion mimicking mesothelioma and is termed as "pseudomesothelioma". A 35-year-old male presented with a pleural mass encasing the whole of the right lung without any pleural effusion and investigations revealed it to be primary signet ring cell adenocarcinoma of the lung.
Subject(s)
Adult , Carcinoma, Signet Ring Cell/complications , Diagnosis, Differential , Humans , Lung Neoplasms/complications , Male , Mesothelioma/diagnosis , Pleural Neoplasms/diagnosisABSTRACT
Patients presenting with acute disseminated intravascular coagulation (DIC) as the first symptom of malignancy are rare. A 68-year-old man presented with DIC. On evaluation, he was found to have adenocarcinoma of the stomach. Resection of the growth controlled the DIC for a few days, after which the patient developed altered coagulation parameters and sepsis, and succumbed.
Subject(s)
Acute Disease , Aged , Carcinoma, Signet Ring Cell/complications , Disseminated Intravascular Coagulation/etiology , Humans , Male , Stomach Neoplasms/complicationsABSTRACT
El objetivo es analizar la conducta tomada con dos pacientes portadoras de cáncer de colon con desnutrición grave que no mejoró con las medidas nutricionales habituales. Se presentan los casos clínicos de dos pacientes describiendo su cuadro clínico, los balances nutricionales y los aportes para revertir sus cuadros de desnutrición. Al ver que no regresa se decide hacer una resección de colon con intención curativa y en un segundo tiempo restablecer el tránsito. Em ambas pacientes, resecando el tumor se pudo mejorar su desnutrición. Se discuten las causas de desnutrición en pacientes con cánceres de colon y otras localizaciones